It's made over $2 billion in retail sales, been released on nine formats and clocked up 20 titles - games don't get much bigger than Guitar Hero.
Chances are you've built up a mean set of callouses from your note streak hunting and know the solo to Free Bird better than your phone number - but did you know of the scientific discoveries that have been made thanks to Guitar Hero? Or the incredible records the game has helped set?
Here are 15 pieces of trivia and fact that fans of the series (probably) won't have read before. Rock on.
(Images: Rex; YouTube; Shutterstock)